The radically redesigned display extends behind the two-spoke steering wheel – reminiscent of the S-Class heritage – as a key element of the horizontal alignment. It replaces the traditional instrument cluster and combines numerous other functions in a visually and ergonomically highly sophisticated manner (see "New display concept" section). The entire display unit appears to be free-floating, an impression reinforced by ambience backlighting. 

The high-quality unit formed by the centre air vents and the analogue clock is precisely set into three-dimensional wood trim. For the first time this classic wood trim feature is positioned very low. This creates a second level of decorative trim whose luxurious stitched leather lies in the primary field of vision. Both levels extend elegantly across the entire width of the dashboard and doors. With this layout the designers have created an association with the wingbeat of a bird. The result is an extraordinary impression of width combined with a pleasant, calm ambience.

The visually prominent dashboard is characterised by the striking double-S curve. This already made the preceding model unmistakable, and imparts a feeling of spaciousness, safety and security.

The perfectly coordinated use of materials and colours produces an elegant interior seemingly cast from a single mould. There is generous use of wood trim, especially in the dashboard and centre console. Metallised switch surfaces with pearl-effect paint finishes in three colour shades to suit the interior colour particularly highlight the outstanding quality.

Innovative lighting systems in the form of a continuous light band under the wood trim strips and the central display – a completely new dimension in ambience lighting – and elegant lighting units with stylish details in the headlining enhance the comfortable atmosphere. The number and size of the stowage facilities in the interior have been greatly increased compared to the preceding model.

Passengers in the rear are also seated in first-class – the design and exclusivity of the seats, door panels and all controls are to the same, high standard as the front. If a luxury or reclining seat (Executive seat) is specified for the rear, the backrest inclines backwards into the parcel shelf, which means that legroom is not restricted even in the resting position. As an additional individualisation feature, the "First-Class rear suite" incorporates a Business centre console combining personal comfort with practical convenience (integration of a telephone handset, additional stowage compartments, folding table, etc.). The side finishers of the front seats are formally integrated and feature useful stowage compartments (see "Seats" section for details).

In combination with the first-class quality of materials and outstandingly high perceived value, the decidedly varied range of available appointments emphatically confirms the premium positioning of Mercedes-Benz.The innovative architecture of the interior design, which is based on both additive and integrating features, allows a choice of different and very individual styling in terms of colours and materials.

The standard appointments already meet high expectations. They include leather seat upholstery (long wheelbase), elegantly finished wood trim and surfaces with decorative topstitching. Various leather versions are available as optional extras, differing in their surface finish (e.g. patterned perforations and a hand-quilted look and feel), and also in terms of the relative leather and trim surfaces. The customer also has a choice of five interior colour arrangements combined with five different types of exotic wood trim.

The interior design of the new S-Class was also influenced by the Mercedes‑Benz Advanced Interior Design Studio in Como, whose primary task was also to explore how the highest possible perceived quality can be created. Using the so-called "appreciation model", the designers were able to give free rein to their imagination and look for ways of translating these ideals into series production features. This led to a harmonious and luxurious interior whose design, character and perceived value are unrivalled.